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| Product Name | Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14A (PPP1R14A) protein (His tag) |
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| Description | PPP1R14A is a phosphorylation-dependent inhibitor of smooth muscle myosin phosphatase. Inhibition of PPP1R14A results to increased myosin phosphorylation and enhances smooth muscle contraction in the absence of increased intracellular Ca(2+) concentration. Myosin phosphatase can reverse MYL (myosin light chain) phosphorylation to induce a state of relaxation. However, during agonist-induced contraction at constant Ca2+ concurrent inhibition of myosin phosphatase leads to increases in MYL phosphorylation and tension. These calcium-independent increases in myosin phosphorylation and tension are termed calcium sensitization.Human pregnancy is characterized by the increases of PKN1 expression and CPI-17 phosphorylation in the myometrium. PPP1R14A is mapped to chromosome 19q13.13-q13.2.PPP1R14A binds directly to protein kinase C and casein kinase I. PPP1R14A siRNA decreased the level of merlin phosphorylation and consequently Ras and ERK activity in human tumor cell lines. PKC/CPI-17 mediated pathway in histamine, triggeres cytoskeletal rearrangements causing lung microvascular barrier compromise Synonyms: Protein phosphatase 1 regulatory subunit 14A, 17 kDa PKC-potentiated inhibitory protein of PP1, CPI17, CPI-17, PPP1INL, PPP1R14A |
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| Size | 20 µg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | MGC81874|cpi-17|ppp1inl|CPI-17|im:7147597|ppp1r14a|zgc:110700|PPP1R14A|CPI17|PPP1INL|Cpi17|1110001M11Rik |
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| Gene, Accession, CAS # | Gene ID: 94274 |
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| Catalog # | ABIN805588 |
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| Order / More Info | Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14A (PPP1R14A) protein (His tag) from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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