| 产品详情 |
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| Antigenic Specificity | SKI |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Western Blot: 1:500-1:3000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | SKI Polyclonal Antibody. SKI functions by binding to the Smad proteins and preventing their phosphorylation, thereby inhibiting their ability to bind DNA and activate the transcription of downstream genes. TGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis. This signaling is negatively regulated by Ski, the mammalian homolog of the transforming protein of an avian retrovirus that induces oncogenic transformation of chicken embryo cells, and the related protein SnoN. SnoN is located primarily in the nucleus in cancer tissues or cells, but in the cytoplasm in normal tissues or primary epithelial cells. There are at l |
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| Immunogen | n/a |
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| Other Names | SGS, SKI proto-oncogene, SKV |
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| Gene, Accession # | Entrez: 6497; Uniprot: P12755 |
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| Catalog # | PA5-78166 |
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| Price | |
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| Order / More Info | SKI Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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