| 产品详情 |
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| Antigenic Specificity | Androgen Receptor |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse |
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| Isotype | n/a |
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| Format | peptide affinity purified |
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| Size | 80 µl, 400 µl |
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| Concentration | n/a |
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| Applications | WB, IHC. RUO |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Androgen receptor has 3 major functional domains: the N-terminal domain, DNA-binding domain, and an androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. The gene for this protein contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of the protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations are also associated with complete androgen insensitivity (CAIS). PIAS1 and PIASxalpha function as SUMO-E3 ligases toward androgen receptor; sumoylation of ANDR represses androgen receptor dependent transcription. This Androgen Receptor (ANDR) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 365-392 amino acids from human Androgen Receptor (ANDR). |
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| Immunogen | Human Androgen Receptor (ANDR). |
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| Other Names | ANDR; Androgen receptor; DHTR; Dihydrotestosterone receptor; NR3C4; AR; AIS; AR8; HUMARA; HYSP1; KD; SBMA; SMAX1; TFM; RP11-383C12.1; Nuclear Receptor Subfamily 3,Group C,Member 4; Testicular Feminization; Kennedy Disease |
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| Gene, Accession # | SwissProt: P10275 |
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| Catalog # | abx025053 |
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| Price | |
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| Order / More Info | Androgen Receptor Antibody from ABBEXA |
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| Product Specific References | n/a |
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