产品详情 |
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Antigenic Specificity | PEN2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | purified |
Size | 50 µg |
Concentration | n/a |
Applications | Immunohistochemistry: Assay Dependent, Immunoprecipitation: Assay Dependent, Western Blot: Assay Dependent |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | PEN2 Polyclonal Antibody. Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. |
Immunogen | n/a |
Other Names | MDS033, MSTP064, PEN-2, PEN2, gamma-secretase subunit PEN-2, hematopoietic stem/progenitor cells protein MDS033 |
Gene, Accession # | Entrez: 55851, 66340; Uniprot: Q9CQR7, Q9NZ42 |
Catalog # | 36-7100 |
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Order / More Info | PEN2 Antibody from INVITROGEN ANTIBODIES |
Product Specific References | PubMed: 16449647, 21253592, 21280074, 22496554, 22511769, 23843529, 25429133, 26581893, 28383037, 29215028 |
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