| 产品详情 |
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| Antigenic Specificity | CD40 |
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| Clone | monoclonal |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG2b |
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| Format | allophycocyanin (APC) conjugate |
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| Size | 100 tests |
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| Concentration | n/a |
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| Applications | FCM. RUO |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CD40 is a member of the tumour necrosis factor (TNF) receptor super family, which includes the low affinity nerve growth factor (NGF) receptor and CD95/Fas. CD40 is the receptor for CD40 ligand. CD40 ligand (CD40L, CD154, gp39, and TRAM) belongs to the TNF gene family and is expressed more widely than CD40 predominantly on activated CD4+ T cells. Following interaction with CD40 ligand, CD40 mediates a number of major immunoregulatory functions, central to the control of thymus dependent humoral immunity and may be critical in the development of cell mediated immune responses. Other biological actions include B cell homotypic adhesion, proliferation, immunoglobulin isotype switch, and secretion. Activation of CD40 has also been shown to inhibit the growth of certain B cell lymphomas and to induce the death of transformed cells of mesenchymal or epithelial origin. CD40 is a 48 kD type I glycoprotein also known as BP50. It is a member of the TNFR superfamily primarily expressed on B cells, macrophages, follicular dendritic cells, endothelial cells, fibroblasts, and at low levels on plasma cells. CD40 has been reported to be involved in B cell differentiation, costimulation, isotype class-switching, and protection of B cells from apoptosis. Additionally, CD40 is important for T cell-B cell interactions. |
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| Immunogen | Recombinant protein (Human CD40). |
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| Other Names | CD40; Tumor necrosis factor receptor superfamily member 5; B-cell surface antigen CD40; Bp50; CD40L receptor; CDw40; TNFRSF5; p50; p51; p52; p53; p54; p55; p56; CD antigen CD40; CD40 antigen; TNR5; B-Cells; Cd40 B Cells; MAB TO CD40 B CELLS; MAB TO CD40; MGC9013 |
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| Gene, Accession # | Gene ID: 958, SwissProt: P25942 |
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| Catalog # | abx200258 |
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| Price | |
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| Order / More Info | CD40 Antibody from ABBEXA |
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| Product Specific References | n/a |
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