| 产品详情 |
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| Product Name | XL335 |
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| Description | A potent and selective FXR agonist (EC50 = 4 nM in CV-1 cells transfected with human FXR); selective for FXR over a panel of 15 nuclear receptors at concentrations up to 10 µM; induces a 20-, 13-, and 2-fold increase in mRNA expression for IBABP, BSEP, and SHP, respectively, at a concentration of 1 µM; reduces plasma cholesterol and triglycerides and the area of pre-atherosclerotic lesions in LDLR-/- mice fed a Western diet; decreases hepatic fibrosis in a mouse model of non-alcoholic steatohepatitis |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | FXR 450|Turofexorate Isopropyl|WAY-362450 |
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| Gene, Accession, CAS # | CAS: 629664-81-9 |
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| Catalog # | 23350-10 |
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| Price | |
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| Order / More Info | XL335 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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