| 产品详情 |
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| Antigenic Specificity | MUNC18 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 2 µg/mL, Immunofluorescence: 2 µg/mL, Immunohistochemistry (Frozen): Assay dependent, Immunoprecipitation: Assay dependent, Western Blot: 1:1,000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | MUNC18 Polyclonal Antibody. Munc-18 is a cytosolic brain protein of ~67 kDa which plays a key role in vesicle membrane fusion events with the plasma membrane. Functional interactions have been demonstrated to exist between Munc-18, synaptosomal associated protein of 25 kDa (SNAP-25), synaptobrevin, and syntaxin. Munc-18 is the mammalian homologue of the C. elegans gene unc-18. Mutations in Munc-18 can result in accumulations of acetylcholine and paralytic phenotype suggestive of a neurotransmitter release defect. Munc-18 thus appears to be required by the synaptic vesicle fusion complex. Two Munc-18 isoforms have recently been identified. Munc-18-1 has been shown to be primarily expressed in brain, while Munc-18-2 is expressed in most tissu |
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| Immunogen | n/a |
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| Other Names | MGC146482, hunc18, munc18-1, rbsec1, rop, unc18 |
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| Gene, Accession # | Entrez: 20910, 25558, 6812; Uniprot: O08599, P61764, P61765 |
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| Catalog # | PA1-742 |
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| Price | |
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| Order / More Info | MUNC18 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 11054418, 16785322, 21123556, 27410964, 7768895 |
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