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| Antigenic Specificity | MULT1 (NKG2D Ligand) |
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| Clone | 5D10 |
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| Host Species | Armenian Hamster |
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| Reactive Species | mouse, rat |
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| Isotype | IgG |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Flow Cytometry: 1 µg/test, Immunohistochemistry (Frozen): Assay-Dependent |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | MULT1 (NKG2D Ligand) Monoclonal Antibody (5D10), eBioscience™. ULBP1 is the ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach t |
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| Immunogen | n/a |
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| Other Names | RAET1I, N2DL-1, NKG2D ligand 1, NKG2DL1, UL16-binding protein 1, alcan-beta, retinoic acid early transcript 1I |
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| Gene, Accession # | Entrez: 77777 |
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| Catalog # | 14-5863-82 |
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| Price | |
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| Order / More Info | MULT1 (NKG2D Ligand) Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 22072975, 24802191, 29540781 |
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