| 产品详情 |
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| Antigenic Specificity | 4EBP1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 ug |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 2 µg/mL, Western Blot: 2.5-10 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | 4EBP1 Polyclonal Antibody. The translation of mRNA in eukaryotic cells is regulated by the presence of amino acids through multiple mechanisms. One such mechanism involves the evolutionarily conserved serine/threonine kinase TOR (Target of rapamycin, also known as mTOR), which regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors. One downstream target of TOR is the eukaryotic initiation factor 4E binding protein 1 (4E-BP1) whose phosphorylation prevents its association with eIF4E, preferentially stimulating translation of mRNAs containing long, highly structured 5'-UTRs. Rapamycin inhibits TOR resulting in reduced cell growth and reduced rates of cell cycle and cell proliferat |
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| Immunogen | n/a |
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| Other Names | 4E-BP1, 4EBP1, BP-1, PHAS-I; eIF4E-binding protein 1; eukaryotic translation initiation factor 4E-binding protein 1; phosphorylated heat- and acid-stable protein regulated by insulin 1 |
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| Gene, Accession # | Entrez: 13685, 1978; Uniprot: Q13541, Q60876 |
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| Catalog # | PA5-20135 |
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| Price | |
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| Order / More Info | 4EBP1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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