| 产品详情 |
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| Antigenic Specificity | 4EBP1 |
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| Clone | 554R16 |
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| Host Species | Mouse |
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| Reactive Species | human, mouse, rat |
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| Isotype | IgG1, kappa |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 1:250, Immunofluorescence: 1:250, Western Blot: 1:500 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | 4EBP1 Monoclonal Antibody (554R16). Eukaryotic initiation factor 4E binding protein 1 (4E-BP1), also known as PHAS, is a ~20 kDa member of a family of eIF4E-binding proteins whose binding affinity to eIF4E is regulated by its phosphorylation. It inhibits cap-dependent translation by binding to eIF4E on the same site that overlaps the binding site for eIF4G, preventing its binding to the latter and eventually leading to an increase in mRNA translation. The phosphorylation of 4E-BP1 is critical in determining cell fate by controlling translation initiation and apoptotic potency. 4E-BP1 is hyperphosphorylated in response to several external stimuli including hormones, growth factors, mitogens, cytokines and G-protein-coupled receptors and in r |
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| Immunogen | n/a |
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| Other Names | 4EBP1, EIF4EBP1, Eukaryotic translation initiation factor 4E binding protein 1, Insulin-stimulated EIF-4E binding protein PHAS-I, P/OKCL.6, PHAS-1, PHAS-I |
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| Gene, Accession # | Entrez: 116636, 13685, 1978; Uniprot: Q13541, Q60876, Q62622 |
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| Catalog # | AHO1382 |
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| Price | |
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| Order / More Info | 4EBP1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 20383065, 20926374 |
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