| 产品详情 |
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| Product Name | AICAR |
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| Description | MW: 258.2. AICAR is an adenosine analog that when phosphorylated forms 5-aminoimidazole-4-carboxamide-1-D-ribofuranosyl-5'-monophosphate (ZMP) which proceeds to activate adenosine monophosphate-activated protein kinase (AMPK). This process in turn stimulates glucose uptake by skeletal muscle in an insulin-dependent manner. Autophagy is initiated by the UNC-51-like kinase 1/2 complex (ULK1 and ULK2). Under basal conditions, autophagy is negatively regulated due to the phosphorylation of ULK1 at serine-757 by mTORC1. During starvation, autophagy is positively regulated by ULK1/2 when it is phosphorylated at serine-555 and serine-777 by AMPK. Therefore, the activation of AMPK by AICAR, in turn will induce autophagy. |
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| Size | 10 mg, 50 mg |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | N1-(β-D-Ribofuranosyl)-5-aminoimidazole-4-carboxamide |
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| Gene, Accession, CAS # | CAS: 2627-69-2 |
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| Catalog # | abx076506 |
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| Price | |
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| Order / More Info | AICAR from ABBEXA |
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| Product Specific References | n/a |
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| 产品资料 |
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