| 产品详情 |
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| Product Name | Epoxomicin |
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| Description | MW: 554.7. Epoxomicin is a cell permeable, potent and selective proteasome inhibitor originally isolated from Actinomycetes strain based on its potent in vivo antitumor activity. It is a more potent inhibitor of the chymotrypsin-like activity of the proteasome than lactacystin. Epoxomicin also blocks trypsin-like and PGPH activities of the proteasome and regulates antigen presentation at non-toxic doses. It effectively inhibits NF-κB activation in vitro and potently blocks inflammation in vivo in the mouse ear edema assay. The ubiquitin-proteasome system (UPS) and autophagy serve as two complementary, reciprocally regulated protein degradation systems, thus inhibition of UPS by Epoxomicin activates autophagy. |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | N-Acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyloxiranyl]carbonyl]butyl]-L-threoninamide |
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| Gene, Accession, CAS # | CAS: 134381-21-8 |
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| Catalog # | abx076828 |
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| Price | |
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| Order / More Info | Epoxomicin from ABBEXA |
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| Product Specific References | n/a |
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