| 产品详情 |
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| Product Name | K02288 |
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| Description | An ALK1 and ALK2 inhibitor (IC50s = 1.8 and 1.1 nM, respectively) that can prevent BMP4-induced SMAD1/5/8 pathway activation in vitro (IC50 = 100 nM) without affecting TGF-β signaling; less selective for ALK3, 4, 5, and 6 subtypes and the type II BMP receptor ActRIIA (IC50s = 34.4, 302, 321, 6.4, and 220 nM, respectively) |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | stem cells bone morphogenetic protein type I receptor BMP activin receptor-like kinase ALK SMAD complexes translocate nucleus induce transcriptional activation normal development tissue repair ALK1 ALK2 fibrodysplasia ossificans progressive cancer inhibitor intracellular signaling inhibit bone-related research biochemical biochemistry transcription factor K-02288 2-aminopyridine-based prevent BMP4-induced SMAD1/5/8 pathway in vitro dorsalization zebrafish embryo biology disease model musculoskeletal dysplasia ALK-1 ALK-2 |
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| Gene, Accession, CAS # | CAS: 1431985-92-0 |
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| Catalog # | 16678-1 |
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| Price | |
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| Order / More Info | K02288 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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