| 产品详情 |
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| Antigenic Specificity | BRCA1 |
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| Clone | MU |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG2b, Kappa |
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| Format | biotin conjugate |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 1:10-1:2000, Immunofluorescence: 1:10-1:2000, Immunoprecipitation: 1:10-1:500, Western Blot: 2-4 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | BRCA1 Monoclonal Antibody (MU), Biotin. BRCA1 (breast and ovarian cancer susceptibility protein 1) is a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor in combination with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as BASC (for BRCA1 associated genome surveillance complex). BRCA1 associates with RNA polymerase II, and through the C terminal domain, also interacts with histone deacetylase complex. The BRCA1 protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in the BRCA1 gene are responsible for approximately 40% of inherited breast cancers and more th |
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| Immunogen | n/a |
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| Other Names | BRCAI, BRCC1, BROVCA1, IRIS, PNCA4, PPP1R53, PSCP, RNF53, BRCA1/BRCA2-containing complex, subunit 1, RING finger protein 53, breast and ovarian cancer susceptibility protein 1, breast and ovarian cancer sususceptibility protein 1, breast cancer type 1 susceptibility protein, protein phosphatase 1, regulatory subunit 53 |
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| Gene, Accession # | Entrez: 672; Uniprot: P38398 |
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| Catalog # | MA5-16055 |
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| Price | |
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| Order / More Info | BRCA1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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