| 产品详情 |
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| Antigenic Specificity | BRCA1 |
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| Clone | 8F7 |
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| Host Species | Mouse |
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| Reactive Species | human, mouse |
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| Isotype | IgG1, kappa |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin): Assay dependent, Immunoprecipitation: Assay dependent, Western Blot: 1-10 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | BRCA1 Monoclonal Antibody (8F7). BRCA1 (breast and ovarian cancer susceptibility protein 1) is a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor in combination with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as BASC (for BRCA1 associated genome surveillance complex). BRCA1 associates with RNA polymerase II, and through the C terminal domain, also interacts with histone deacetylase complex. The BRCA1 protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in the BRCA1 gene are responsible for approximately 40% of inherited breast cancers and more than 80% |
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| Immunogen | n/a |
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| Other Names | Breast Cancer 1, Breast Cancer 1 Early Onset, Breast Ovarian Cancer Susceptibility, IRIS, Papillary Serous Carcinoma Of The Peritoneum, PSCP, RNF53 |
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| Gene, Accession # | Entrez: 12189, 672; Uniprot: P38398, P48754 |
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| Catalog # | MA1-23162 |
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| Price | |
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| Order / More Info | BRCA1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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