| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | BRCA1 |
|---|
| Clone | 17F8 |
|---|
| Host Species | Mouse |
|---|
| Reactive Species | human, mouse |
|---|
| Isotype | IgG1 |
|---|
| Format | purified |
|---|
| Size | 100 µl |
|---|
| Concentration | n/a |
|---|
| Applications | ChIP assay: Assay-dependent, ELISA: Assay dependent, Immunocytochemistry: 1 µg/mL, Immunofluorescence: 1 µg/mL, Immunohistochemistry (Paraffin): Assay dependent, Immunoprecipitation: Assay dependent, Western Blot: 1:500-1:3000 |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | BRCA1 Monoclonal Antibody (17F8). BRCA1 (breast and ovarian cancer susceptibility protein 1) is a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor in combination with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as BASC (for BRCA1 associated genome surveillance complex). BRCA1 associates with RNA polymerase II, and through the C terminal domain, also interacts with histone deacetylase complex. The BRCA1 protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in the BRCA1 gene are responsible for approximately 40% of inherited breast cancers and more than 80% |
|---|
| Immunogen | n/a |
|---|
| Other Names | Breast Cancer 1, Breast Cancer 1 Early Onset, Breast Ovarian Cancer Susceptibility, IRIS, Papillary Serous Carcinoma Of The Peritoneum, PSCP, RNF53 |
|---|
| Gene, Accession # | Entrez: 12189, 672; Uniprot: P38398, P48754 |
|---|
| Catalog # | MA1-23160 |
|---|
| Price | |
|---|
| Order / More Info | BRCA1 Antibody from INVITROGEN ANTIBODIES |
|---|
| Product Specific References | PubMed: 29362392 |
|---|
| 产品资料 |
|
|