| 产品详情 |
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| Product Name | ADX-47273 |
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| Description | A positive allosteric modulator of mGluR5 (EC50s = 0.17 and 0.23 µM for potentiation of glutamate activity in HEK293 cells expressing rat mGluR5 and primary astrocyte cultures, respectively); selective for mGluR5 over rat mGluR1 and human mGluR1 and mGluR4 at 10 µM; decreases the conditioned avoidance response, apomorphine-induced climbing, as well as PCP-, apomorphine-, and amphetamine-induced locomotor activity in rats in a dose-dependent manner; improves recall in a novel object recognition test and reduces impulsivity in the 5CSRTT from 0.1-50 mg/kg; enhances reversal learning in mice in the Morris water maze test, |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 851881-59-9 837413-22-6 ADX47273 mGluR-5 1 4 HEK-293 5-CSRTT anti-psychotic |
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| Gene, Accession, CAS # | CAS: 851881-60-2 |
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| Catalog # | 17987-1 |
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| Order / More Info | ADX-47273 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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