| 产品详情 |
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| Product Name | GW 9662 |
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| Description | The peroxisome proliferator-activated receptor γ (PPARγ) is the nuclear receptor responsible for transducing the therapeutic activity of the thiazolidinediones. Thiazolidinediones are a group of structurally related synthetic PPARγ agonists with antidiabetic actions in vivo. Rosiglitazone (BRL 49653) is a prototypical thiazolidinedione and has served as a reference compound for this class. There are many PPARγ agonists, including 15-deoxy-.DELTA.12,14-prostaglandin J2 and azelaoyl PAF, which are naturally derived. However, only a few antagonists have been reported. GW 9662 blocks the PPARγ-induced differentiation of monocytes to osteoclasts by >90% at a dose of 0.1 µM. It is therefore a much more potent antagonist than BADGE, which is another reported PPARγ antagonist. |
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| Size | 50 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | GW-9662 GW9662 ligands ppar.gamma. ppargamma peroxisome proliferator-activated nuclear endocrinology receptors antagonists atherosclerosis |
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| Gene, Accession, CAS # | CAS: 22978-25-2 |
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| Catalog # | 70785-50 |
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| Order / More Info | GW 9662 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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