| 产品详情 |
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| Product Name | AZD 0156 |
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| Description | An inhibitor of ATM kinase (IC50s = 0.04 and 0.57 nM in enzyme and cell-based assays, respectively); selective for ATM over other PIKK family kinases including DNA-PK, mTOR, PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ (IC50s = 0.14, 0.20, 0.32, 1.8, 1.1, and 0.27 µM, respectively, in enzyme assays); enhances the antitumor activity of irinotecan in an SW620 colon cancer mouse xenograft model at 20 mg/kg and olaparib in an HBCx-10 breast cancer PDX mouse model at 5 mg/kg, leading to tumor regression in both models |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | AZD0156 DNAPK anti-tumor SW-620 HBCx10 |
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| Gene, Accession, CAS # | CAS: 1821428-35-6 |
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| Catalog # | 25648-10 |
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| Price | |
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| Order / More Info | AZD 0156 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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