| 产品详情 |
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| Antigenic Specificity | SKP2 |
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| Clone | SKP2-8D9 |
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| Host Species | Mouse |
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| Reactive Species | human, nonhuman primate |
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| Isotype | IgG1, kappa |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | ELISA: 0.1-1.0 µg/mL, Immunoprecipitation: 5 µg, Western Blot: 2 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | SKP2 Monoclonal Antibody (SKP2-8D9). Skp2 (S-phase Kinase-associated Protein 2) belongs to the family of F-box proteins that interact with the Cyclin A-Cdk2 complex. Skp2 is essential for the G1-S transition in both transformed cells and diploid fibroblasts. Biochemical and genetic experiments have demonstrated that Skp2 is required for the ubiquitination and consequent degradation of p27 in cultured mammalian cells and in vitro reconstitution assays. In normal tissues, Skp2 is expressed in tonsil and placenta. In tumor tissues, Skp2 is expressed widely, in some colon, prostate, pancreas, and skin cancers, with high expression in lung, breast, ovarian, and endometrial cancers. Research suggests that Skp2 plays a role in oncogenesis, particu |
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| Immunogen | n/a |
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| Other Names | SKP2, FBXL1, S-phase kinase-associated protein 2, Cyclin-A/CDK2-associated protein p45, F-box protein Skp2, F-box/LRR-repeat protein 1, p45skp2 |
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| Gene, Accession # | Entrez: 6502; Uniprot: Q13309 |
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| Catalog # | 32-3300 |
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| Price | |
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| Order / More Info | SKP2 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 11943729, 12188931, 12840033, 15004027, 15096506, 15314162, 15355997, 15605273, 15679784, 16774918, 16924241, 16943200, 17308064, 18305219, 18716061, 19596792, 19828607, 20378537, 20465575, 20883453, 21182779, 21358672, 22045027, 23950209, 24356446, 24574749, 24732797, 25264277, 25395170, 25818643, 25843293, 26963853, 28962365, 29317652 |
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