| 产品详情 |
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| Antigenic Specificity | VHL |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse |
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| Isotype | n/a |
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| Format | purified |
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| Size | 400 µL |
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| Concentration | n/a |
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| Applications | Flow Cytometry: 1:10-1:50, Immunocytochemistry: 1:10-1:50, Immunofluorescence: 1:10-1:50, Immunohistochemistry: 1:10-1:50, Western Blot: 1:1000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | VHL Polyclonal Antibody. Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of VHL gene is the basis of familial inheritance of VHL syndrome. The protein is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. |
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| Immunogen | n/a |
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| Other Names | Von Hippel-Lindau disease tumor suppressor; pVHL; Protein G7; VHL |
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| Gene, Accession # | Entrez: 22346, 7428; Uniprot: P40337, P40338 |
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| Catalog # | PA5-13487 |
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| Price | |
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| Order / More Info | VHL Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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