| 产品详情 |
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| Antigenic Specificity | VHL |
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| Clone | Ig33 |
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| Host Species | Mouse |
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| Reactive Species | human, mouse |
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| Isotype | IgG1, kappa |
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| Format | purified |
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| Size | 500 µL |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 2 µg/mL, Immunofluorescence: 2 µg/mL, Immunohistochemistry (Paraffin): 2-4 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | VHL Monoclonal Antibody (Ig33). Molecular genetic studies suggest that VHL is a tumor-suppressor gene. Alterations in the von Hippel-Lindau (VHL) gene are correlated with a diverse group of neoplasms including hemangioblastoma, clear cell renal carcinoma (RCC), and pheochromocytoma. Two transcriptional elongation factors, Elongin B and C, are shown to bind in vitro and in vivo to a short, colinear region of the VHL protein (pVHL) that is frequently mutated in human tumors. It is proposed that pVHL functions in vivo as a negative regulator of transcription elongation. |
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| Immunogen | n/a |
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| Other Names | elongin binding protein, pVHL, protein G7, von Hippel-Lindau disease tumor suppressor |
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| Gene, Accession # | Entrez: 22346, 7428; Uniprot: P40337, P40338 |
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| Catalog # | MA5-13940 |
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| Price | |
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| Order / More Info | VHL Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 15269293, 17532031, 18043042, 18707725, 21299348, 24446253 |
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