| 产品详情 |
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| Antigenic Specificity | PPM1D |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 400 µL |
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| Concentration | n/a |
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| Applications | Western Blot: 1:1000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | PPM1D Polyclonal Antibody. PPM1D is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. Expression of this PPM1D gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. The PPM1D gene is located in a c |
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| Immunogen | n/a |
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| Other Names | Protein phosphatase 2C delta isoform; PP2C-delta; p53-induced protein phosphatase 1; Protein phosphatase magnesium-dependent 1 delta; WIP1 |
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| Gene, Accession # | Entrez: 8493; Uniprot: O15297 |
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| Catalog # | PA5-15541 |
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| Price | |
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| Order / More Info | PPM1D Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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