| 产品详情 |
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| Antigenic Specificity | PPM1A |
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| Clone | 7F12 |
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| Host Species | Mouse |
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| Reactive Species | human, mouse, nonhuman primate |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 100 ug |
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| Concentration | n/a |
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| Applications | Flow Cytometry: 1:200 - 1:400, Western Blot: 1:500 - 1:2000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | PPM1A Monoclonal Antibody (7F12). The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively sp |
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| Immunogen | n/a |
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| Other Names | n/a |
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| Gene, Accession # | Entrez: 19042, 5494; Uniprot: P35813, P49443 |
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| Catalog # | MA5-17154 |
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| Price | |
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| Order / More Info | PPM1A Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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