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| Product Name | SCIO 469 hydrochloride |
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| Description | Selective, ATP-competitive p38 inhibitor (IC50 = 9 nM for p38α in vitro). Displays approximately 10-fold selectivity for p38α over p38β and 2000-fold selectivity for p38α over 20 other kinases. Reduces p38α phosphorylation in multiple myeloma cells in vitro and in vivo; activity results in decreased tumor burden and angiogenesis in murine models of multiple myeloma. Also enhances bortezomib-induced cytotoxicity against multiple myeloma cells. Purity 98%. MW (observed): 549.46 |
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| Size | 50 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 6-Chloro-5-[[(2R,5S)-4-[(4-fluorophenyl)methyl]-2,5-dimethyl-1-piperazinyl]carbonyl]-N,N,1-trimethyl-α-oxo-1H-Indole-3-acetamide hydrochloride |
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| Gene, Accession, CAS # | CAS: 309913-83-5 |
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| Catalog # | 3528/50 |
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| Order / More Info | SCIO 469 hydrochloride from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 25554418 |
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| 产品资料 |
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