| 产品详情 |
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| Product Name | GNE 2861 |
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| Description | Inhibitor of group II p21 activated kinases (PAK; IC50 values are 7.5, 126 and 36 nM for PAK4, PAK5 and PAK6, respectively). Displays selectivity for group II PAK over a panel of 222 kinases. Inhibits tumor cell proliferation, migration and invasion in two breast cancer cell lines. Also sensitizes tamoxifen-resistant breast cancer cell lines to tamoxifen (Cat. No. 6342) via PAK4-dependent regulation of estrogen receptor α (ERα) target gene expression. Purity 98%. MW (observed): 406.48 |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1-[2-[1-(2-Amino-4-pyrimidinyl)-2-[(2-methoxyethyl)amino]-1H-benzimidazol-6-yl]ethynyl]cyclohexanol |
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| Gene, Accession, CAS # | CAS: 1394121-05-1 |
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| Catalog # | 6490/5 |
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| Order / More Info | GNE 2861 from TOCRIS BIOSCIENCE
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| Product Specific References | n/a |
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| 产品资料 |
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