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| Product Name | ANA 12 |
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| Description | TrkB receptor antagonist. Demonstrates a 2-site mode of action, preventing activation by BDNF non-competitively (IC50 values are 45.6 nM and 41.1 μM for the high and low affinity sites respectively). Displays no effect on TrkA and TrkC in an assay of neurite outgrowth. Demonstrates antidepressant properties. Also exhibits anti-seizure effects in an ischemia-induced neonatal seizure model by blocking down-regulation of KCC2. Purity 99%. MW (observed): 407.49 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[2-[[(Hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]benzo[b]thiophene-2-carboxamide |
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| Gene, Accession, CAS # | CAS: 219766-25-3 |
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| Catalog # | 4781/10 |
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| Price | |
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| Order / More Info | ANA 12 from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 26594153, 27659207, 29886238 |
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