| 产品详情 |
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| Product Name | PF-2545920 |
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| Description | A potent inhibitor of PDE10A (IC50 = 1.26 nM for the human recombinant enzyme); selective for PDE10A over other PDEs with IC50 values ranging from 1.7 to >10 µM; increases cAMP and cGMP production as well as phosphorylation of CREB and GluR1 in mouse striatum in a dose-dependent manner; reduces apomorphine-induced climbing behavior in mice (ID50 = 0.375 mg/kg) and disrupts the conditioned avoidance response in mice and rats (ID50s = 0.441 and 1.079 mg/kg, respectively); reverses (+)-MK-801-induced deficits in prepulse inhibition and social odor recognition in rats, |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1037309-45-7 1292799-56-4 PF2545920 MP10 PDE-10A GluR-1 MK801 MP-10 |
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| Gene, Accession, CAS # | CAS: 898562-94-2 |
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| Catalog # | 18266-1 |
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| Price | |
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| Order / More Info | PF-2545920 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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