| 产品详情 |
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| Product Name | FK 506 |
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| Description | Potent calcineurin (protein phosphatase 2B) inhibitor that requires FK 506-binding protein 12 (FKBP12) for activity (IC50 = 3 nM). Inhibits secretion of IL-1, IL-2 (IC50 = 1 nM), IL-3, IL-4, IL-6 (IC50 = 35 nM), GM-CSF, TNFα (IC50 = 10 nM), IFNγ and Myc from activated T cells in vitro. Exhibits potent immunosuppressive, neuroprotective and anticonvulsant activity in vivo. Analog also available.. Purity 99%. MW (observed): 804.02 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-e. Tacrolimus, Fujimycin |
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| Gene, Accession, CAS # | CAS: 104987-11-3 |
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| Catalog # | 3631/10 |
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| Order / More Info | FK 506 from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 21273417, 22902539, 23141069, 23386250, 23918927, 23989619, 24667246, 24973091, 25071439, 25558061, 25810886, 26589795, 27246912, 27340371, 27545504 |
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