| 产品详情 |
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| Antigenic Specificity | HP1 alpha |
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| Clone | monoclonal |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | biotin conjugate |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Immunoprecipitation: Assay Dependent, Western Blot: 2 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | HP1 alpha Monoclonal Antibody, Biotin. Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, where it mediates gene silencing. It has been shown that mammalian methyltransferases that selectively methylate histone H3 on lysine-9 generate a binding site for HP1 proteins, a family of heterochromatic adaptor molecules implicated in both gene silencing and supranucleosomal chromatin structure. High-affinity in vitro recognition of a methylated histone H3 peptide by HP1 requires a functional chromodomain. Thus, the HP1 chromodomain is a specific interaction motif for the methyl epitope on lysine-9 of histone H3. In vivo, heterochromatin association of HP1 proteins is lost in Suv39h double-null pri |
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| Immunogen | n/a |
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| Other Names | HP1 alpha |
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| Gene, Accession # | Entrez: 23468; Uniprot: P45973 |
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| Catalog # | 730046 |
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| Price | |
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| Order / More Info | HP1 alpha Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 26121405 |
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