| 产品详情 |
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| Antigenic Specificity | PROX1 |
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| Clone | 5G10 |
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| Host Species | Mouse |
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| Reactive Species | human, mouse |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Immunofluorescence: 1:50, Western Blot: 1:500 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | PROX1 Monoclonal Antibody (5G10). The expression pattern of the Prox1 homeo box gene suggests that it has a role in a variety of embryonic tissues, including lens. Analysis of mRNA reveals that Prox mRNA is present in many different human tissues and that lens demonstrated the highest level. Homozygous Prox1-null mice die at midgestation from multiple developmental defects, and a targeted effect on lens development has been reported. Prox1 inactivation caused abnormal cellular proliferation, downregulated expression of the cell cycle inhibitors Cdkn1b and Cdkn1c, misexpression of E-cadherin, and excessive apoptosis. Consequently, mutant lens cells failed to polarize and elongate properly, resulting in a hollow lens. The Prox1 gene is expres |
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| Immunogen | n/a |
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| Other Names | PROX-1, homeobox prospero-like protein PROX1, prospero homeobox protein 1, prospero-related homeobox |
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| Gene, Accession # | Entrez: 19130, 5629; Uniprot: P48437, Q92786 |
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| Catalog # | MA1-203 |
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| Price | |
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| Order / More Info | PROX1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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