| 产品详情 |
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| Product Name | Linaclotide |
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| Description | A peptide agonist of the guanylate cyclase C receptor (Ki = 16.4 nM in a radioligand binding assay using mouse intestinal mucosa); stimulates fluid secretion and cGMP concentration in jejunal loops isolated from wild-type mice but not guanylate cyclase C receptor null mice; increases intestinal transit in wild-type mice when administered at a dose of 100 µg/kg; reduces the number of phosphorylated ERK-positive dorsal horn neurons in the thoracolumbar spinal cord, a marker of nociceptive signaling, following noxious colorectal distension and mechanical hypersensitivity in a mouse model of TNBS-induced colitis |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Linzess constipation IBS Constella |
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| Gene, Accession, CAS # | CAS: 851199-59-2 |
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| Catalog # | 24085-5 |
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| Price | |
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| Order / More Info | Linaclotide from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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