| 产品详情 |
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| Product Name | Oxymetazoline (hydrochloride) |
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| Description | An agonist of α1- and α2-ARs (Kds = 6, 320, and 390 nM for α1A-, α1B-, and α1D-ARs, respectively, Ki = 15 nM for α2-AR); acts as an agonist of 5-HT1 receptors (Kds = 4.68, 25.7, 5.01 nM for 5-HT1A, 5-HT1B, and 5-HT1D, respectively); increases intracellular calcium levels in CHO cells transfected with the α1A-AR (EC50 = 40.7 nM); acts as a partial agonist of the α2-AR in perfused rat heart (IC50 = 63 nM and EC50 = 13.5 nM for norepinephrine release); acts as an agonist and antagonist of the 5-HT1C receptor in the presence of methiothepin and clonidine, respectively (Kds = 110 and 257 nM, respectively); inhibits forskolin-stimulated adenylate cyclase activity (EC50s = 18.6, 24.0, and 44.7 nM in tissues expressing high levels of 5-HT1A, 5-HT1B, and 5-HT1D receptors, respectively) and accumulation of inositol phosphates (EC50 = 269 nM in pig choroid plexus preparations, which highly express 5-HT1C receptors); decreases nasal pressure in dogs by 6.9% when used at a dose of 0.2 µg/kg |
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| Size | 1 g |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | SCH 9384 |
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| Gene, Accession, CAS # | CAS: 2315-02-8 |
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| Catalog # | 23826-1 |
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| Order / More Info | Oxymetazoline (hydrochloride) from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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