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| Antigenic Specificity | Phospho-Cortactin (Tyr421) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 1:250, Immunofluorescence: 1:250, Western Blot: 1:250 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Phospho-Cortactin (Tyr421) Polyclonal Antibody. Cortactin (Cttn) is a ubiquitous actin-binding protein that was originally identified as a substrate for Src. It contributes to the organization of the actin cytoskeleton and cell shape. Cortactin also plays a role in the formation of lamellipodia and cell migration. It is accumulated in peripheral, actin-enriched structures of cells suggesting that cortactin facilitates actin network formation. Cortactin has four major domains of interest the N-terminal acidic (NTA) and tandem repeats domains and the C-terminal proline-rich and SH3 Domains. NTA associates with the Arp2/3 and WASP complex at F-actin branches. Cortactin is involved in promoting cell motility and invasion, including a critical r |
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| Immunogen | n/a |
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| Other Names | 1110020L01Rik, Amplaxin, cortactin, CTTN, EMS1, ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate), FLJ34459, Oncogene EMS1, Src substrate cortactin, SRC8 |
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| Gene, Accession # | Entrez: 13043, 2017; Uniprot: Q14247, Q60598 |
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| Catalog # | 44-854G |
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| Price | |
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| Order / More Info | Phospho-Cortactin (Tyr421) Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 12925758, 15972849, 17446433, 19138410, 19349302, 20733006, 23248771 |
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