| 产品详情 |
| Edit |   |
|---|
| Product Name | UNC569 |
|---|
| Description | A TAM family kinase inhibitor (IC50s = 2.9, 37, and 48 nM for Mer, Axl, and Tyro3, respectively); antiproliferative against ALL cells (IC50s = 0.5 and 1.2 µM for 697 and Jurkat cell lines, respectively); inhibits Mer phosphorylation (IC50s = 141 and 193 nM in 697 and Jurkat cell lines, respectively); decreases tumor burden by 47.8% relative to controls in human MYC transgenic zebrafish (4 µM); delays leukemia onset, reduces CNS infiltration, and prolongs survival of mice implanted with patient-derived Mer-expressing ALL primary cells (10 mg/kg) |
|---|
| Size | 10 mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | UNC-569 RTK tyro-3 anti-proliferative erk-1 2 erk1 erk2 central nervous system |
|---|
| Gene, Accession, CAS # | CAS: 1350547-65-7 |
|---|
| Catalog # | 22966-10 |
|---|
| Price | |
|---|
| Order / More Info | UNC569 from CAYMAN CHEMICAL COMPANY |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|