| 产品详情 |
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| Product Name | YU238259 |
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| Description | An inhibitor of homology-dependent DNA repair; lethal to BRCA2-/- but not BRCA2+/+ PEO1/4 cells (LD50s = 8.7 and >100 µM, respectively); selectively inhibits HDR over NHEJ; decreases the number of U20S cells with ionizing radiation-induced BRCA1 foci but not 53BP1 or pDNA-PK foci; increases the number of ionizing radiation-induced DSBs in DLD-1 cells; cytotoxic to BRCA2-/- DLD-1, ATM-/- GM05849, and PTEN-/- U251 cells from 1-20 µM; delays tumor growth and increases survival in a BRCA2-/-, but not a BRCA+/+, DLD-1 mouse xenograft model at 3 mg/kg , |
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| Size | 25 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | YU-238259 BRCA-1 2 PEO-1 PEO4 U-20S U20-S U-20-S 53-BP1 53BP-1 53-BP-1 pDNAPK DLD1 GM-05849 U-251 |
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| Gene, Accession, CAS # | CAS: 1943733-16-1 |
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| Catalog # | 25452-25 |
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| Price | |
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| Order / More Info | YU238259 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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