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| Antigenic Specificity | ZNF451 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 400 µl |
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| Concentration | n/a |
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| Applications | Western Blot: 1:1000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | ZNF451 Polyclonal Antibody. E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins (PubMed:26524493, PubMed:26524494). Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation (By similarity). Has no activity with SUMO1 (PubMed:26524493). Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11' (PubMed:26524493). Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9' (PubMed:24324267). Plays a role in regulating the trans |
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| Immunogen | n/a |
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| Other Names | Zinc finger protein 451; Coactivator for steroid receptors; ZNF451; COASTER; KIAA0576; KIAA1702 |
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| Gene, Accession # | Entrez: 26036; Uniprot: Q9Y4E5 |
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| Catalog # | PA5-72615 |
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| Price | |
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| Order / More Info | ZNF451 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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