| 产品详情 |
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| Antigenic Specificity | JAK3 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Western Blot: 1:500-1:3000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | JAK3 Polyclonal Antibody. JAK3 is a Janus Activating Kinase (JAK), which is a number of related tyrosine kinases involved in cytoplasmic signal transduction. In response to a varitety of cytokine or related factors (e.g., interferon, interleukins), JAKs are activated via phosphorylation at 2 adjacent tyrosine residues. The activation of JAKs can lead to the phosphorylation of STAT (signal transducers and activatiors of transcription) proteins, which dimerize and translocate to the nucleus. Once translocated to the nucleus, the STAT proteins can modify transcription of numerous genes, including interferon-stimulated genes. JAK2 is required for the IFN gamma-receptor complex initiation and JAK1 functions as an amplifier. However, active JAK1 |
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| Immunogen | n/a |
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| Other Names | JAK3_HUMAN, JAKL, Janus kinase 3, L JAK, LJAK |
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| Gene, Accession # | Entrez: 3718; Uniprot: P52333 |
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| Catalog # | PA5-78030 |
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| Price | |
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| Order / More Info | JAK3 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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