| 产品详情 |
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| Antigenic Specificity | CD146 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin): 1:20-1:200, Western Blot: Assay Dependent |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CD146 Polyclonal Antibody. CD146 (MCAM) is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. CD146 is expressed at cell-cell junctions in all endothelial cells, and has also been observed in other normal and malignant cell types. In addition to its recognized role as a calcium-independent cell adhesion molecule, CD146 may also act as a signal transduction molecule in the recruitment of Fyn kinase, and in the subsequent tyrosine-phosphorylation of intracellular proteins involved in actin cytoskeleton assembly. CD146 plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. CD146 expression may allow melanoma cells to interact with cellular elements |
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| Immunogen | n/a |
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| Other Names | CD146, MUC18, MCAM, Gicerin, S-endo 1 endothelial-associated antigen, cell surface glycoprotein MUC18, cell surface glycoprotein P1H12, melanoma adhesion molecule, melanoma-associated antigen A32, melanoma-associated antigen MUC18 |
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| Gene, Accession # | Entrez: 4162; Uniprot: P43121 |
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| Catalog # | 34-6800 |
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| Price | |
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| Order / More Info | CD146 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 23712706, 24204598 |
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