| 产品详情 |
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| Antigenic Specificity | IFIT1 |
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| Clone | OTI3G8 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 100 µl |
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| Concentration | n/a |
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| Applications | Flow Cytometry: 1:100, Immunocytochemistry: 1:100, Immunofluorescence: 1:50-1:100, Immunohistochemistry (Paraffin): 1:50, Western Blot: 1:500-1:1000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | IFIT1 Monoclonal Antibody (OTI3G8). Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2 |
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| Immunogen | n/a |
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| Other Names | C56, G10P1, GARG-16, IFI-56, IFI-56K, IFI56, IFIT-1, IFNAI1, ISG56, RNM561, Interferon, alpha-inducible protein (MW 56kD), interferon-induced 56 kDa protein, interferon-induced protein 56 |
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| Gene, Accession # | Entrez: 3434; Uniprot: P09914 |
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| Catalog # | MA5-25050 |
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| Price | |
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| Order / More Info | IFIT1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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