| 产品详情 |
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| Antigenic Specificity | Claudin 5 |
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| Clone | 4C3C2 |
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| Host Species | Mouse |
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| Reactive Species | human, mouse, rat |
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| Isotype | IgG1 |
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| Format | Alexa Fluor 488 conjugate |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | ELISA: Assay Dependent, Immunocytochemistry: Assay Dependent, Immunofluorescence: 5-10 µg/mL, Immunohistochemistry: 5-10 µg/mL, Immunoprecipitation: Assay Dependent, Western Blot: Assay Dependent |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Claudin 5 Monoclonal Antibody (4C3C2), Alexa Fluor 488. Initially only transmembrane protein known to be associated with tight junctions was occludin, an ~65 kDa protein with four transmembrane domains. Despite widespread expectation, a critical structural role for occludin in TJ strands was ruled out by the observation of apparently normal tight junctions formed between cells disrupted at both occludin alleles. A closer examination of isolated tight junctions uncovered two related ~22 kDa, four-transmembrane domain proteins, claudin-1 and claudin-2, with no similarity to occludin. In contrast to occludin, which induces only a small number of short strands at cell-cell contact sites when introduced into fibroblasts lacking tight junctions, |
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| Immunogen | n/a |
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| Other Names | AWAL, BEC1, CPETRL1, TMVCF, TMDVCF, claudin-5, transmembrane protein deleted in VCFS, transmembrane protein deleted in velocardiofacial syndrome |
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| Gene, Accession # | Entrez: 12741, 65131, 7122; Uniprot: O00501, O54942, Q9JKD6 |
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| Catalog # | 352588 |
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| Price | |
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| Order / More Info | Claudin 5 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 23217714, 23748444, 25083995, 25414188, 26030524, 26047027, 26630461, 26687981, 27907215, 28396408, 28717251 |
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