| 产品详情 |
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| Antigenic Specificity | ARH |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 80 µl, 400 µl |
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| Concentration | n/a |
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| Applications | WB, IHC. RUO |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | LDLRAP1 is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. This adapter protein is required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). LDLRAP1 may be required for LDL binding and internalization but not for receptor clustering in coated pits. This protein may facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits, and may also be involved in the internalization of other LDLR family members. Mutations in the LDLRAP1 gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia. This ARH (LDLRAP1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 277-306 amino acids from the C-terminal region of human ARH (LDLRAP1). |
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| Immunogen | Human ARH. |
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| Other Names | ARH; LDL receptor adaptor protein; ARH2; FHCB1; FHCB2; MGC34705; DKFZp586D0624; low density lipoprotein receptor adaptor protein 1; RP11-70P17.2; autosomal recessive hypercholesterolemia protein; LDLRAP1; Low density lipoprotein receptor adapter protein 1 |
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| Gene, Accession # | SwissProt: Q5SW96 |
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| Catalog # | abx033819 |
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| Price | |
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| Order / More Info | ARH Antibody from ABBEXA |
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| Product Specific References | n/a |
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