| 产品详情 |
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| Product Name | MK-0752 |
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| Description | A potent, reversible inhibitor of γ-secretase, reducing the cleavage of APP to Aβ40 in SH-SY5Y cells with an IC50 value of 5 nM; orally bioavailable and crosses the blood-brain barrier, as orally administered MK-0752 dose-dependently reduces the generation of new amyloid β protein in the brain of rhesus monkeys |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 952578-?68-?6 656810-87-6 biochemical inhibitor inhibit Alzheimer's research neuroscience cancer stem cell research MK0752 potent γ-secretase protease complex cleave single-pass transmembrane protein Notch receptor precursor β-amyloid APP domain reversible Aβ40 Aβ-40 cleavage reduce human neuroblastoma SH-SY5Y SHSY5Y orally bioavailable blood-brain barrier dose-dependently generation new rhesus monkey pathway breast cancer tumorgraft chemotherapy drug docetaxel mice tumor |
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| Gene, Accession, CAS # | CAS: 471905-41-6 |
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| Catalog # | 16706-5 |
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| Order / More Info | MK-0752 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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