| 产品详情 |
| Edit |   |
|---|
| Product Name | MK-0557 |
|---|
| Description | A potent antagonist of NPY receptor Y5 (Kis = 1.3, 0.79, 0.74, and 1.4 nM for human, rhesus monkey, mouse, and rat receptors, respectively); >7,500-fold selective for Y5 over other NPY receptors and lacks activity in a panel of 180 receptors, enzymes, and ion channels at concentrations up to 1 µM; increases intracellular calcium in CHO cells expressing the human Y5 receptor in a concentration-dependent manner; reduces body weight gain in wild-type and diet-induced obese mice when administered at a dose of 30 mg/kg; reduces retroperitoneal fat pad weight, epididymal and mesenteric fat pad weights, leptin levels, and food intake in lean mice fed a high-fat diet |
|---|
| Size | 25 mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | 935765-76-7 MK0557 Y-5 Chinese ovary hamster |
|---|
| Gene, Accession, CAS # | CAS: 328232-95-7 |
|---|
| Catalog # | 22134-25 |
|---|
| Price | |
|---|
| Order / More Info | MK-0557 from CAYMAN CHEMICAL COMPANY |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|