| 产品详情 |
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| Antigenic Specificity | p14ARF |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | ELISA: 1:100-1:2000, Immunohistochemistry (Paraffin): 1:100-1:500, Western Blot: 1:500-1:2500 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | p14ARF Polyclonal Antibody. The INK4a-ARF locus is comprised of two tumor suppressors, p16INK4a and p14ARF. These two proteins are encoded through differential splicing of alternative first exons. The p16INK4a (exon 1alpha) protein inhibits the cyclin D-dependent kinases (CDK) that control the phosphorylation of the Rb protein and cell proliferation. The p14ARF gene product complexes with the MDM2 protein within the nucleus, thus modulating the activity of the p53 protein. P14ARF is a potent tumor suppressor in the presence of wild-type p53, while mutant p53 substantially reduces growth inhibition by p14ARF. |
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| Immunogen | n/a |
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| Other Names | ARF, CDK4 inhibitor p16INK4, CDK4I, CDKN2, CDKN2A, Cell cycle negative regulator beta, CMM2, Cyclin dependent kinase inhibitor 2A, Cyclin dependent ki |
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| Gene, Accession # | Entrez: 1029; Uniprot: P42771 |
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| Catalog # | PA1-16662 |
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| Price | |
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| Order / More Info | p14ARF Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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