| 产品详情 |
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| Antigenic Specificity | p14ARF |
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| Clone | ARF 4C6/4 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG2a |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | ELISA: Assay dependent, Immunocytochemistry: Assay dependent, Immunofluorescence: Assay dependent, Immunoprecipitation: Assay dependent, Western Blot: Assay dependent |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | p14ARF Monoclonal Antibody (ARF 4C6/4). The INK4a locus on chromosome 9p21 is frequently affected in human tumors. It encodes two structurally distinct tumor suppressor proteins, p16INK4a and the alternative reading frame protein, ARF (p14ARF in human and P19ARF in mouse). These two proteins interact with the upstream proteins: retinoblastoma protein and p53 tumor suppressors, respectively. Each of these proteins has a role in the senescence of primary cells, activates pathways for cell cycle control and tumor suppression. The p14ARF (or P19ARF in mouse) proteins can induce both G1 and G2 phase arrest in a manner that depends on functional p53. The mouse and human ARF proteins have different functions in tumor suppression; this distinction |
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| Immunogen | n/a |
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| Other Names | ARF, CDK4I, CDKN2, CMM2, INK4, INK4a, MLM, MTS1, TP16, p14, p14ARF, p16, p16INK4, p16INK4a, p19, p19Arf |
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| Gene, Accession # | Entrez: 1029; Uniprot: P42771 |
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| Catalog # | MA1-20219 |
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| Price | |
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| Order / More Info | p14ARF Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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