| 产品详情 |
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| Antigenic Specificity | p14ARF |
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| Clone | 14P02 (DCS-240) |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1, kappa |
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| Format | purified |
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| Size | 500 µL |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 1:10-1:200, Immunofluorescence: 1:10-1:200, Immunoprecipitation: 2 µg/mL, Western Blot: 2-4 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | p14ARF Monoclonal Antibody (14P02 (DCS-240)). The INK4a-ARF locus encodes two unrelated proteins both of which function in tumor suppression. p14ARF arrests the cell cycle in a p53-dependent manner. p14ARF binds to mdm2 and promotes the rapid degradation of mdm2 proteinrequired for mdm2 modification and concurrent p53 stabilization and accumulation. This interaction is mediated by the exon 1beta-encoded N-terminal domain of p14ARF and a C-terminal region of mdm2. Deletion of the ARF-INK4a locus simultaneously impairs both the INK4a-cyclin D/cdk4-RB and the ARF-mdm2-p53 pathways. |
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| Immunogen | n/a |
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| Other Names | CDK4 inhibitor p16-INK4, cell cycle negative regulator beta, cyclin-dependent kinase 4 inhibitor A, cyclin-dependent kinase inhibitor 2A, multiple tumor suppressor 1 |
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| Gene, Accession # | Entrez: 1029; Uniprot: P42771 |
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| Catalog # | MA5-14260 |
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| Price | |
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| Order / More Info | p14ARF Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 11306450, 11520274, 12175554, 12771937, 14966292, 15064750, 15169789, 15199070, 15318938, 15582998, 16267006, 16306780, 16631606, 16847458, 16891203, 16957780, 17112319, 17369842, 23308265, 23449888, 25675183, 27356744 |
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