| 产品详情 |
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| Product Name | ETC-159 |
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| Description | A potent, orally bioavailable inhibitor of PORCN (IC50s = 18.1 and 70 nM for mouse and Xenopus PORCN, respectively); inhibits β-catenin reporter activity (IC50 = 2.9 nM) and reduces the interaction of Wnt with its carrier protein WLS via decreased Wnt palmitoleation in STF3A cells; inhibits PA-1 teratocarcinoma colony formation in soft agar (IC50 = 35 nM); reduces tumor growth in a dose-dependent manner in mice carrying a mouse mammary tumor virus LTR-Wnt1 transgene and in A-1 and NCCIT teratocarcinoma mouse xenograft models (1-10 mg/kg); reduces growth and induces differentiation in colon adenocarcinoma mouse xenograft models that contain RSPO translocations, |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | ETC-1922159? |
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| Gene, Accession, CAS # | CAS: 1638250-96-0 |
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| Catalog # | 24104-5 |
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| Price | |
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| Order / More Info | ETC-159 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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