| 产品详情 |
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| Antigenic Specificity | CD95 (APO-1/Fas) |
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| Clone | DX2 |
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| Host Species | Mouse |
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| Reactive Species | canine, human |
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| Isotype | IgG1, kappa |
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| Format | eFluor 450 conjugate |
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| Size | 100 Tests |
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| Concentration | n/a |
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| Applications | Flow Cytometry: 5 µL (0.5 µg)/test |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CD95 (APO-1/Fas) Monoclonal Antibody (DX2), eFluor 450, eBioscience™. CD95 (Fas, APO-1), a 46 kDa transmembrane glycoprotein, is a cell death receptor of the TNFR superfamily. Stimulation of CD95 results in aggregation of its intracellular death domains, formation of the death-inducing signaling complex (DISC) and activation of caspases. In type I cells caspase 3 is activated by high amounts of caspase 8 generated at the DISC, in type II cells low concentration of caspase 8 activates pathway leading to the release of cytochrome c from mitochondria and activation of caspase 3 by cytochom c. Besides its roles in induction of apoptosis, Fas also triggers pro-inflammatory cytokine responses. |
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| Immunogen | n/a |
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| Other Names | ALPS1A, APO-1, APT1, Apo-1 Fas, CD95, FAS1, FASTM, TNFRSF6 |
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| Gene, Accession # | Entrez: 355, 486469; Uniprot: P25445 |
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| Catalog # | 48-0959-42 |
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| Order / More Info | CD95 (APO-1/Fas) Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 21088216, 21690242, 21949371, 24354871, 25270871, 26544625, 28320962, 28810658, 28969030 |
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