| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | CD95 (APO-1/Fas) |
|---|
| Clone | 15A7 |
|---|
| Host Species | Mouse |
|---|
| Reactive Species | mouse |
|---|
| Isotype | IgG1, kappa |
|---|
| Format | Super Bright 436 conjugate |
|---|
| Size | 100 µg |
|---|
| Concentration | n/a |
|---|
| Applications | Flow Cytometry: 1 µg/test |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | CD95 (APO-1/Fas) Monoclonal Antibody (15A7), Super Bright 436, eBioscience™. CD95 (Fas, APO-1), a 46 kDa transmembrane glycoprotein, is a cell death receptor of the TNFR superfamily. Stimulation of CD95 results in aggregation of its intracellular death domains, formation of the death-inducing signaling complex (DISC) and activation of caspases. In type I cells caspase 3 is activated by high amounts of caspase 8 generated at the DISC, in type II cells low concentration of caspase 8 activates pathway leading to the release of cytochrome c from mitochondria and activation of caspase 3 by cytochom c. Besides its roles in induction of apoptosis, Fas also triggers pro-inflammatory cytokine responses. |
|---|
| Immunogen | n/a |
|---|
| Other Names | n/a |
|---|
| Gene, Accession # | Entrez: 14102; Uniprot: P25446 |
|---|
| Catalog # | 62-0951-82 |
|---|
| Price | |
|---|
| Order / More Info | CD95 (APO-1/Fas) Antibody from INVITROGEN ANTIBODIES |
|---|
| Product Specific References | PubMed: 29300052 |
|---|
| 产品资料 |
|
|